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Design and Synthesis of a Potent Histone Deacetylase Inhibitor

โœ Scribed by Liu, Tao; Kapustin, Galina; Etzkorn, Felicia A.


Book ID
115441338
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
191 KB
Volume
50
Category
Article
ISSN
0022-2623

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## Abstract Various structurally modified analogues of FR235222 (**1**), a natural tetrapeptide inhibitor of mammalian histone deacetylases, were prepared in a convergent approach. The design of the compounds was aimed to investigate the effect of structural modifications of the tetrapeptide core i