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Conformational analogues of Oxamflatin as histone deacetylase inhibitors

✍ Scribed by Dear, Anthony E.; Liu, Hong B.; Mayes, Penelope A.; Perlmutter, Patrick

Book ID: 119944495
Publisher: Royal Society of Chemistry
Year: 2006
Tongue: English
Weight: 198 KB
Volume: 4
Category: Article
ISSN: 1477-0520
DOI: 10.1039/B608213K

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## Abstract In cancer cells, an imbalance often exists between histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities, and various drug companies are actively seeking competitive HDAC inhibitors for chemotherapeutic intervention. Cancer cells appear to be more sensitive than nont