Platelet monoamine oxidase molecular activity in demented patients
โ Scribed by P. Bongioanni; F. Gemignani; B. Boccardi; M. Borgna; B. Rossi
- Publisher
- Springer Milan
- Year
- 1997
- Tongue
- English
- Weight
- 603 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1590-1874
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Platelet monoamine oxidase (MAO) is under genetic control. A lower MAO activity in chronic schizophrenia has repeatedly been reported, and it has been suggested that reduced activity of this enzyme reflects an increased vulnerability to schizophrenia. To test this hypothesis platelet MAO was determi
Platelet monoamine oxidase activity was determined in 52 unipolar depressive patients, 26 patients with bipolar affective disorder and 48 controls using phenylethylamine as substrate. Unipolar depressive patients of either sex and bipolar depressive women showed significantly higher platelet MAO act
To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels we