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Platelet monoamine oxidase activity in first-degree relatives of schizophrenic patients

โœ Scribed by Peter Propping; Waltraut Friedl

Publisher
Springer
Year
1979
Tongue
English
Weight
659 KB
Volume
65
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

Platelet monoamine oxidase (MAO) is under genetic control. A lower MAO activity in chronic schizophrenia has repeatedly been reported, and it has been suggested that reduced activity of this enzyme reflects an increased vulnerability to schizophrenia. To test this hypothesis platelet MAO was determined in 65 first-degree relatives of 22 schizophrenic index patients and in matched healthy controls. No difference in mean activity between the two samples could be detected, suggesting that reduced MAO activity in schizophrenia is more likely to be a phenomenon secondary to the disease. A significant parent-offspring correlation of MAO activities was obtained.

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