Increased platelet monoamine oxidase activity in affective disorders
โ Scribed by M. A. Reveley; Vivette Glover; M. Sandler; A. Coppen
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 426 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0033-3158
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โฆ Synopsis
Platelet monoamine oxidase activity was determined in 52 unipolar depressive patients, 26 patients with bipolar affective disorder and 48 controls using phenylethylamine as substrate. Unipolar depressive patients of either sex and bipolar depressive women showed significantly higher platelet MAO activity than controls. Women had higher activity than men. Neither age nor serum lithium level correlated with enzyme activity and there was no significant change in activity after the institution of lithium treatment.
๐ SIMILAR VOLUMES
To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels we