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Genome screen for platelet monoamine oxidase (MAO) activity

✍ Scribed by Saccone, Nancy L.; Rice, John P.; Rochberg, Nan; Goate, Alison; Reich, Theodore; Shears, Shantia; Wu, William; Nurnberger, John I.; Foroud, Tatiana; Edenberg, Howard J.; Li, Ting-Kai

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 22 KB
Volume: 88
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19991015)88:5<517::aid-ajmg15>3.0.co;2-b

No coin nor oath required. For personal study only.

✦ Synopsis

To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01: D6S1018 (p=0.0004), D2S1328 (p=0.008), and D2S408 (p=0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N=409) gave maximal lod scores of 2.0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.

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