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Monoamine oxidase genes polymorphisms and mood disorder

✍ Scribed by Muramatsu, Taro; Matsushita, Sachio; Kanba, Shigenobu; Higuchi, Susumu; Manki, Hiroshi; Suzuki, Eiji; Asai, Masahiro

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 16 KB
Volume: 74
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19970919)74:5<494::aid-ajmg7>3.0.co;2-o

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✦ Synopsis

We investigated a genetic association between mood disorders (bipolar and unipolar) and the alleles of monoamine oxidase (MAO) A and B (MAOA and MAOB). One hundred and twelve unrelated Japanese patients (60 bipolar, 52 unipolar) and 100 controls were genotyped for three markers of MAOA and for one marker of MAOB. No statistically significant difference in the distribution of the alleles existed between cases and controls. Therefore, our results did not support the involvement of the alleles at MAOA and MAOB in the etiology of mood disorder.

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