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Analysis of GNAZ gene polymorphism in bipolar affective disorder

✍ Scribed by Saito, Takuya; Papolos, Demitri F.; Chernak, Danielle; Rapaport, Mark H.; Kelsoe, John R.; Lachman, Herbert M.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
16 KB
Volume
88
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19990820)88:4<324::aid-ajmg7>3.0.co;2-m

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✦ Synopsis

Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein ␣ subunit gene G␣z (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation polymorphism analysis. The frequency of this polymorphism was determined in a control population (n=84) and in patients with BPD (n=88). The data showed a statistical trend toward a difference in the distribution of alleles in patients with BPD compared with control subjects (chi square=3.2, 1 df, P=0.073, two-tailed). No significant difference was detected when the GNAZ polymorphism was analyzed in control subjects and schizophrenia patients (n=63, P=0.92). These data continue to provide some support for a BPD susceptibility gene on 22q11, possibly in linkage disequilibrium with the GNAZ 309 polymorphism.

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