✦ LIBER ✦

Serotonin transporter (5-HTT) gene and bipolar affective disorder

✍ Scribed by Esterling, Lisa E.; Yoshikawa, Takeo; Turner, Gordon; Badner, Judy A.; Bengel, Dietmar; Gershon, Elliot S.; Berrettini, Wade H.; Detera-Wadleigh, Sevilla D.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 15 KB
Volume: 81
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19980207)81:1<37::aid-ajmg7>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

Interactions with antidepressants, as well as other biochemical evidence, implicate the serotonin transporter 5-HTT in the etiology of affective disorders. However, genetic studies have produced conflicting results concerning an association of 5-HTT with bipolar disorder. We examined a variable number tandem repeat in the regulatory region of this gene to investigate the possible contribution of 5-HTT to bipolar disorder susceptibility in a 22-pedigree series. By affected-sib-pair analysis and the transmission/disequilibrium test, we found no significant linkage or association of 5-HTT to bipolar disorder. During the course of this study, we adapted a PCR technique designed to amplify long templates to replicating long GC stretches with complex structure. We also refined the location of 5-HTT by radiation hybrid mapping, placing the locus between D17S1294 and SHGC11022 on 17q11.2.

📜 SIMILAR VOLUMES

Serotonin transporter gene (5-HTT) polym

Serotonin transporter gene (5-HTT) polymorphisms and compulsive buying

✍ Devor, Eric J.; Magee, Harry J.; Dill-Devor, Rebecca M.; Gabel, Janelle; Black, 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 9 KB 👁 1 views

We examined a panel of 21 patients diagnosed with compulsive buying for two DNA sequence polymorphisms found in the gene that encodes the serotonin transport (5-HTT). One polymorphism, found in the promoter region of the 5-HTT gene, involves a 44-base pair (bp) deletion, and the other, found in the

Investigation of the human serotonin 6 (

Investigation of the human serotonin 6 (5-HT6) receptor gene in bipolar affective disorder and schizophrenia

✍ Vogt, Ina R.; Shimron-Abarbanell, Daphne; Neidt, Helge; Erdmann, Jeanette; Cicho 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 52 KB

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that mediates a wide range of central nervous functions by activating multiple 5-HT receptor subtypes. A possible irregularity of serotonergic neurotransmission has been implicated in a variety of neuropsychiatric diseases. In the present s

No association of the tryptophan hydroxy

No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder

✍ Furlong, Robert A.; Ho, Luk; Rubinsztein, Judy S.; Walsh, Cathy; Paykel, Eugene 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 10 KB 👁 1 views

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylas

Bipolar affective disorder, chromosome 1

Bipolar affective disorder, chromosome 16p13.3, and recessive disease genes

✍ Ewald, Henrik; Kruse, Torben A. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 4 KB 👁 1 views

Genetic associations with clinical chara

Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder

✍ Ho, Luk W.; Furlong, Robert A.; Rubinsztein, Judy S.; Walsh, Cathy; Paykel, Euge 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 30 KB 👁 1 views

Genetic factors may be associated with disease subtype as well as susceptibility. We have therefore typed polymorphisms at the serotonin transporter, dopamine receptor, tryptophan hydroxylase, tyrosine hydoxylase, and monoamine oxidase A (MAOA) loci in 139 unipolar and 131 bipolar patients and inves

Association analysis of the 5-HT2C recep

Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder

✍ Oruc˘, L.; Verheyen, G.R.; Furac˘, I.; Jakovljević, M.; Ivezić, S.; Raeymaekers, 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 16 KB 👁 1 views

We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. No significant associations were found in the total patient sample. However, when the individua