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Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder

✍ Scribed by Oruc˘, L.; Verheyen, G.R.; Furac˘, I.; Jakovljević, M.; Ivezić, S.; Raeymaekers, P.; Broeckhoven, C. Van

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 16 KB
Volume: 74
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19970919)74:5<504::aid-ajmg10>3.0.co;2-g

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✦ Synopsis

We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. No significant associations were found in the total patient sample. However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5-HTR2c and P = 0.049 for 5-HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women. Am. J. Med. Genet. 74: 504-506, 1997.

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