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Association study of the 5-HT6 receptor gene in schizophrenia

✍ Scribed by Shinkai, Takahiro; Ohmori, Osamu; Kojima, Hideki; Terao, Takeshi; Suzuki, Takashi; Abe, Kazuhiko

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 7 KB
Volume: 88
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19990416)88:2<120::aid-ajmg4>3.0.co;2-y

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✦ Synopsis

Serotonergic (5-hydroxytryptamine; 5-HT) transmission may play an important role in the treatment and/or pathogenesis of schizophrenia. Previous studies reported that several atypical antipsychotic agents have high affinities for the 5-HT 6 receptor. The 5-HT 6 receptor gene polymorphism might contribute to the genetic background of this disorder. One hundred and fifty unrelated patients with schizophrenia and 150 unrelated healthy controls were genotyped for a biallelic polymorphism (267C/T) at the 5-HT 6 receptor gene. No significant positive association between the 5-HT 6 receptor genotype and schizophrenia was observed. Our results suggests that the 267C/T polymorphism of the 5-HT 6 receptor gene may not be involved in the susceptibility to schizophrenia.

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