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Photoaffinity Analogues of Farnesyl Pyrophosphate Transferable by Protein Farnesyl Transferase

✍ Scribed by Chehade, Kareem A. H.; Kiegiel, Katarzyna; Isaacs, Richard J.; Pickett, Jennifer S.; Bowers, Katherine E.; Fierke, Carol A.; Andres, Douglas A.; Spielmann, H. Peter


Book ID
126162313
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
229 KB
Volume
124
Category
Article
ISSN
0002-7863

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## Abstract The synthesis of new bioisosteric analogues of farnesyl pyrophosphate where a vinyl pyrophosphonate replaced the pyrophosphate moiety is described. These compounds have been prepared using a Horner–Wadsworth–Emmons procedure and a modified Michelson reaction. They have been evaluated fo