## Abstract The synthesis of new bioisosteric analogues of farnesyl pyrophosphate where a vinyl pyrophosphonate replaced the pyrophosphate moiety is described. These compounds have been prepared using a Horner–Wadsworth–Emmons procedure and a modified Michelson reaction. They have been evaluated fo
Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine
✍ Scribed by M. Lamothe; D. Perrin; D. Blotières; M. Leborgne; S. Gras; D. Bonnet; B.T. Hill; S. Halazy
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 325 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
So far, treatment with anti-cancer agents has failed to achieve satisfactory results in hepatocellular carcinoma. In the process of hepatocarcinogenesis, ras has been shown to play a role. ras requires a farnesyl moiety for activation. It has been found that UCF I -C (manumycin). an antibiotic, inhi
Fermentation optimization for the fungus Aspergillus fumigatus F93 was performed to amplify the most promising biological activity. Twelve active variables were analysed and optimized by the Plackett-Burman design, consisting of 16 experiments. Farnesyl protein transferase inhibitory activity showed
## Abstract We reported recently that roscovitine (ROSC), a selective cyclin‐dependent kinase (CDK) inhibitor, arrests human MCF‐7 breast cancer cells in G~2~ phase of the cell cycle, and concomitantly induces apoptosis. Human MCF‐7 breast cancer cells are known to express elevated levels of c‐Ha‐R