Phosphorylation of nucleoside derivatives with aryl phosphoramidochloridates
β Scribed by J.H. van Boom; P.M.J. Burgers; R. Crea; W.C.M.M. Luyten; A.B.J. Vink; C.B. Reese
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 799 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4020
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Novel aryl Nβphosphonamidothionate derivatives of nucleosides as membraneβsoluble prodrugs of bioactive free nucleotides have been prepared by phosphochloridothioate chemistry. Unprotected nucleosides, for example uridine and adenosine, were used; phosphorylation took place selectively
The nucleophilic aromatic substitution of halogen in metal arene p-complexes h 6 -(ArF)Cr(CO) 3 and [h 6 -(ArHal)FeCp] + [PF 6 ] -(Hal=F,Cl) with phosphoryl-stabilized carbanions ZCH 2 P(O)(OEt) 2 (Z=COOEt, CN) allows the synthesis of metal p-complexes of a-EWG-substituted arylmethylphosphonates in
The reaction of Ξ²-dialkylaminocrotontriles with phosphorus(III) halides has been investigated. The basicity of the dialkylamino group influences the phosphorylation markedly, with pyrrolidine being the amine of choice. It was found that a solvent and the ratio of triethylamine play a significant rol