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A Stepwise one-pot synthesis of aryl N-phosphonamidothionate derivatives of nucleosides

✍ Scribed by Zhi-Wei Miao; Hua Fu; Guang-Zhong Tu; Ji-Gang Zhu; Hui-Wang Ai; Yu-Fen Zhao

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
94 KB
Volume
14
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Novel aryl N‐phosphonamidothionate derivatives of nucleosides as membrane‐soluble prodrugs of bioactive free nucleotides have been prepared by phosphochloridothioate chemistry. Unprotected nucleosides, for example uridine and adenosine, were used; phosphorylation took place selectively at the 5′‐position. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:62–66, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10080

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