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A Stepwise One-Pot Synthesis of Aryl N-Phosphonamidothionate Derivatives of Nucleosides.

✍ Scribed by Zhi-Wei Miao; Hua Fu; Guang-Zhong Tu; Ji-Gang Zhu; Hui-Wang Ai; Yu-Fen Zhao

Publisher
John Wiley and Sons
Year
2003
Weight
113 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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A Stepwise one-pot synthesis of aryl N-p
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✍ Zhi-Wei Miao; Hua Fu; Guang-Zhong Tu; Ji-Gang Zhu; Hui-Wang Ai; Yu-Fen Zhao 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB

## Abstract Novel aryl N‐phosphonamidothionate derivatives of nucleosides as membrane‐soluble prodrugs of bioactive free nucleotides have been prepared by phosphochloridothioate chemistry. Unprotected nucleosides, for example uridine and adenosine, were used; phosphorylation took place selectively

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