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Phosphonate Analogues of α-Ketoglutarate Inhibit the Activity of the α-Ketoglutarate Dehydrogenase Complex Isolated from Brain and in Cultured Cells †

✍ Scribed by Bunik, Victoria I.; Denton, Travis T.; Xu, Hui; Thompson, Charles M.; Cooper, Arthur J. L.; Gibson, Gary E.

Book ID
125530712
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
133 KB
Volume
44
Category
Article
ISSN
0006-2960

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## Abstract Mitochondrial dysfunction has been implicated in cell death in many neurodegenerative diseases. Diminished activity of the α‐ketoglutarate dehydrogenase complex (KGDHC), a key and arguably rate‐limiting enzyme of the Krebs cycle, occurs in these disorders and may underlie decreased brai