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Selective enrichment of cholinergic neurons with the α-ketoglutarate dehydrogenase complex in rat brain

✍ Scribed by Calingasan, Noel Y.; Baker, Harriet; Sheu, Kwan-Fu Rex; Gibson, Gary E.

Book ID: 122585288
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 358 KB
Volume: 168
Category: Article
ISSN: 0304-3940
DOI: 10.1016/0304-3940(94)90452-9

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## Abstract Diminished activity of the α‐ketoglutarate dehydrogenase complex (KGDHC), an important component of the tricarboxylic acid (TCA) cycle, occurs in several neurological diseases. The effect of specific KGDHC inhibitors [phosphonoethyl ester of succinyl phosphonate (PESP) and the carboxy e