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Mild reduction in the activity of the α-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis

✍ Scribed by Qingli Shi; Øystein Risa; Ursula Sonnewald; Gary E. Gibson


Book ID
111181366
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
468 KB
Volume
109
Category
Article
ISSN
0022-3042

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## Abstract Diminished activity of the α‐ketoglutarate dehydrogenase complex (KGDHC), an important component of the tricarboxylic acid (TCA) cycle, occurs in several neurological diseases. The effect of specific KGDHC inhibitors [phosphonoethyl ester of succinyl phosphonate (PESP) and the carboxy e