Abnormality of the α-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease
✍ Scribed by Dr. Kwan-Fu Rex Sheu; Arthur J. L. Cooper; Kichiko Koike; Masahiko Koike; J. Gordon Lindsay; John P. Blass
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 755 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0364-5134
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## Abstract Diminished activity of the α‐ketoglutarate dehydrogenase complex (KGDHC), an important component of the tricarboxylic acid (TCA) cycle, occurs in several neurological diseases. The effect of specific KGDHC inhibitors [phosphonoethyl ester of succinyl phosphonate (PESP) and the carboxy e
## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset (320 families, AAO ≥65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we