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Inhibition of the α-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation

✍ Scribed by Hsueh-Meei Huang; Hui Zhang; Hui Xu; Gary E Gibson


Book ID
117617975
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
244 KB
Volume
1637
Category
Article
ISSN
0925-4439

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## Abstract Diminished activity of the α‐ketoglutarate dehydrogenase complex (KGDHC), an important component of the tricarboxylic acid (TCA) cycle, occurs in several neurological diseases. The effect of specific KGDHC inhibitors [phosphonoethyl ester of succinyl phosphonate (PESP) and the carboxy e