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Phase I trial of olaparib in combination with cisplatin for the treatment of patients with advanced breast, ovarian and other solid tumors

✍ Scribed by Balmana, J.; Tung, N. M.; Isakoff, S. J.; Grana, B.; Ryan, P. D.; Saura, C.; Lowe, E. S.; Frewer, P.; Winer, E.; Baselga, J.; Garber, J. E.

Book ID
125531432
Publisher
Oxford University Press
Year
2014
Tongue
English
Weight
144 KB
Volume
25
Category
Article
ISSN
0923-7534

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi