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A phase I trial of gemcitabine in combination with patupilone in patients with advanced solid tumors

โœ Scribed by William Schelman; Sherry Morgan-Meadows; Howard Bailey; Kyle Holen; James P. Thomas; Jens Eickhoff; Heidi Brandon; Kate Oliver; Dona Alberti; George Wilding


Publisher
Springer
Year
2008
Tongue
English
Weight
325 KB
Volume
62
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and doseโ€limiting toxicities (DLTs) of bortezomib in combi