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Pharmacokinetic results of a phase I trial of sorafenib in combination with dacarbazine in patients with advanced solid tumors

โœ Scribed by Erich Brendel; Matthias Ludwig; Chetan Lathia; Caroline Robert; Stanislas Ropert; Jean-Charles Soria; Jean-Pierre Armand


Publisher
Springer
Year
2010
Tongue
English
Weight
367 KB
Volume
68
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and doseโ€limiting toxicities (DLTs) of bortezomib in combi