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Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors

โœ Scribed by Antonio Jimeno; Michelle A. Rudek; Thomas Purcell; Daniel A. Laheru; Wells A. Messersmith; Janet Dancey; Michael A. Carducci; Sharyn D. Baker; Manuel Hidalgo; Ross C. Donehower

Publisher
Springer
Year
2007
Tongue
English
Weight
438 KB
Volume
61
Category
Article
ISSN
0344-5704

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A Phase 1 study of UCN-01 in combination
A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies
โœ Paula M. Fracasso; Kerry J. Williams; Ronald C. Chen; Joel Picus; Cynthia X. Ma; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Springer ๐ŸŒ English โš– 451 KB

## Purpose UCN-01 (7-hydroxystaurosporine) is a multi-targeted protein kinase inhibitor that exhibits synergistic activity with DNA-damaging agents in preclinical studies. We conducted a Phase I study to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic, and