A phase I trial of UCN-01 and prednisone in patients with refractory solid tumors and lymphomas
โ Scribed by Shivaani Kummar; Martin E. Gutierrez; Erin R. Gardner; William D. Figg; Giovanni Melillo; Janet Dancey; Edward A. Sausville; Barbara A. Conley; Anthony J. Murgo; James H. Doroshow
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 181 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0344-5704
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## Purpose UCN-01 (7-hydroxystaurosporine) is a multi-targeted protein kinase inhibitor that exhibits synergistic activity with DNA-damaging agents in preclinical studies. We conducted a Phase I study to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic, and
## Background: Ifosfamide and paclitaxel are antineoplastic agents with broad activity and with different mechanisms of action. a phase i trial was conducted to determine the maximum tolerated dose and associated toxicities of these agents when used in combination. ## Methods: Patients with refra