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A Phase I Trial of Bexarotene in Combination With Docetaxel in Patients With Advanced Solid Tumors

✍ Scribed by Shakun M. Malik; Brian Collins; Michael Pishvaian; Pari Ramzi; John Marshall; Jimmy Hwang


Book ID
113544745
Publisher
CIG Media Group, LP.
Year
2011
Tongue
English
Weight
805 KB
Volume
12
Category
Article
ISSN
1525-7304

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi