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Bortezomib in combination with celecoxib in patients with advanced solid tumors: a phase I trial

✍ Scribed by John Hayslip; Uzair Chaudhary; Mark Green; Mario Meyer; Steven Dunder; Carol Sherman; Shanta Salzer; Andrew Kraft; Alberto J Montero


Book ID
115011090
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
216 KB
Volume
7
Category
Article
ISSN
1471-2407

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Phase I clinical trial of bortezomib in
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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi