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A phase I pharmacodynamic trial of bortezomib in combination with doxorubicin in patients with advanced cancer

โœ Scribed by Noelle K. LoConte; James P. Thomas; Dona Alberti; Jennifer Heideman; Kimberly Binger; Rebecca Marnocha; Kyle Utecht; Peter Geiger; Jens Eickhoff; George Wilding; Jill Kolesar

Publisher
Springer
Year
2008
Tongue
English
Weight
326 KB
Volume
63
Category
Article
ISSN
0344-5704

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Phase I clinical trial of bortezomib in
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โœ David P. Ryan; Leonard J. Appleman; Thomas Lynch; Jeffrey G. Supko; Panagiotis F ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 114 KB ๐Ÿ‘ 2 views

## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and doseโ€limiting toxicities (DLTs) of bortezomib in combi