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A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors

✍ Scribed by Bhuvaneswari Ramaswamy; Tanios Bekaii-Saab; Larry J. Schaaf; Gregory B. Lesinski; David M. Lucas; Donn C. Young; Amy S. Ruppert; John C. Byrd; Kristy Culler; Diedre Wilkins; John J. Wright; Michael R. Grever; Charles L. Shapiro

Publisher
Springer
Year
2009
Tongue
English
Weight
224 KB
Volume
66
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi