𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A Phase I trial of weekly lomustine in patients with advanced cancer

✍ Scribed by Charles A. Koller; Carolyn C. Gorski; Robert S. Benjamin; Sewa S. Legha; Nicholas E. Papadopoulos; Carl Plager


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
374 KB
Volume
73
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Long-term intravenous hydroxyurea infusi
✍ Martin S. Blumenreich; Michael J. Kellihan; U. Geetha Joseph; Kim A. Lalley; Eli πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 384 KB

Background. Hydroxyurea is an S-phase specific drug. Constant exposure of tumor cells with a low Sphase fraction to the agent may result in improved cell kill. Because of its short half-life, a continuous intravenous infusion may result in better tumor exposure than intake by mouth. The goal of this

A phase I trial of dactinomycin intraven
✍ Martin S. Blumenreich; Thomas M. Woodcock; Stephen P. Richman; Mariesa K. Jones; πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 English βš– 204 KB πŸ‘ 1 views

Eighteen patients with advanced malignancies refractory to other forms of treatment were given dactinomycin (Act D) as continuous intravenous infusions. Their median age was 51 years (range, 36-67); their median performance status was 50 (range, 40-90) on the Karnofsky scale. Act D was administered

A phase II trial of weekly high dose con
✍ Enrique Aranda; AndrΓ©s Cervantes; Javier Dorta; Esperanza Blanco; Carlos FernΓ‘nd πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 419 KB πŸ‘ 1 views

Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer

Phase I clinical trial of weekly combine
✍ Jacob Lokich πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 70 KB πŸ‘ 1 views

A Phase I and feasibility study of combined docetaxel (D) plus paclitaxel (P) was undertaken to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) for each analogue delivered concomitantly on a weekly schedule. ## METHODS. Patients were accrued in 3-6 patient cohorts to P