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A Phase I study of intermittently dosed vorinostat in combination with bortezomib in patients with advanced solid tumors

✍ Scribed by Deming, Dustin A.; Ninan, Jacob; Bailey, Howard H.; Kolesar, Jill M.; Eickhoff, Jens; Reid, Joel M.; Ames, Matthew M.; McGovern, Renee M.; Alberti, Dona; Marnocha, Rebecca; Espinoza-Delgado, Igor; Wright, John; Wilding, George; Schelman, William R.

Book ID
125358899
Publisher
Springer US
Year
2013
Tongue
English
Weight
151 KB
Volume
32
Category
Article
ISSN
0167-6997

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi