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Phase I study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies

✍ Scribed by Schenk, Erin; Hendrickson, Andrea E. Wahner; Northfelt, Donald; Toft, David O.; Ames, Matthew M.; Menefee, Michael; Satele, Daniel; Qin, Rui; Erlichman, Charles


Book ID
125358913
Publisher
Springer US
Year
2013
Tongue
English
Weight
144 KB
Volume
31
Category
Article
ISSN
0167-6997

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi