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Phase I trial of everolimus, gemcitabine and cisplatin in patients with solid tumors

✍ Scribed by Costello, Brian A.; Borad, Mitesh J.; Qi, Yingwei; Kim, George P.; Northfelt, Donald W.; Erlichman, Charles; Alberts, Steven R.

Book ID
125358941
Publisher
Springer US
Year
2014
Tongue
English
Weight
164 KB
Volume
32
Category
Article
ISSN
0167-6997

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi