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Phase I trial of sunitinib and gemcitabine in patients with advanced solid tumors

✍ Scribed by Joanna M. Brell, Smitha S. Krishnamurthi…

Book ID
120776506
Publisher
Springer
Year
2012
Tongue
English
Weight
177 KB
Volume
70
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi