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A Phase I study of pazopanib in combination with gemcitabine in patients with advanced solid tumors

✍ Scribed by Ruth Plummer, Ayman Madi, Melinda Jeffels…

Book ID
120776543
Publisher
Springer
Year
2012
Tongue
English
Weight
266 KB
Volume
71
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi