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Phase 1 Results From a Study of Romidepsin in Combination With Gemcitabine in Patients With Advanced Solid Tumors

✍ Scribed by Jones, Suzanne F.; Infante, Jeffrey R.; Spigel, David R.; Peacock, Nancy W.; Thompson, Dana S.; Greco, F. Anthony; McCulloch, William; Burris III, Howard A.

Book ID
117993296
Publisher
Informa plc
Year
2012
Tongue
English
Weight
197 KB
Volume
30
Category
Article
ISSN
0735-7907

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi