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Phase I trial of 4-demethoxydaunorubicin with single i.v. doses

โœ Scribed by Kaplan, S.; Martini, A.; Varini, M.; Togni, P.; Cavalli, F.

Book ID
122817240
Publisher
Elsevier Science
Year
1982
Weight
463 KB
Volume
18
Category
Article
ISSN
0277-5379

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Phase I trial of 4-demethoxydaunorubicin
Phase I trial of 4-demethoxydaunorubicin (idarubicin) with single oral doses
โœ S. Kaplan; C. Sessa; Y. Willems; M. A. Pacciarini; V. Tamassia; F. Cavalli ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer US ๐ŸŒ English โš– 454 KB

Twenty-four patients with a variety of solid tumors entered a Phase I trial with 4-demethoxydaunorubicin, a new analogue of daunorubicin. The drug was given as a single oral dose of 10-60 mg/m 2 repeated every 3-4 weeks. Leukopenia was the dose-limiting toxicity. Other toxic effects included mild t