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Good tolerance of weekly oral idarubicin: (4-demethoxydaunorubicin): A phase I study with pharmacology

✍ Scribed by Howard Hochster; Michael Green; Leonard Liebes; James L. Speyer; James Wernz; Ronald Blum; Franco Muggia


Publisher
Springer
Year
1990
Tongue
English
Weight
438 KB
Volume
26
Category
Article
ISSN
0344-5704

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πŸ“œ SIMILAR VOLUMES


Phase I trial of 4-demethoxydaunorubicin
✍ S. Kaplan; C. Sessa; Y. Willems; M. A. Pacciarini; V. Tamassia; F. Cavalli πŸ“‚ Article πŸ“… 1984 πŸ› Springer US 🌐 English βš– 454 KB

Twenty-four patients with a variety of solid tumors entered a Phase I trial with 4-demethoxydaunorubicin, a new analogue of daunorubicin. The drug was given as a single oral dose of 10-60 mg/m 2 repeated every 3-4 weeks. Leukopenia was the dose-limiting toxicity. Other toxic effects included mild t

A phase II study of oral idarubicin (4-d
✍ Nicholas S. A. Stuart; Michael H. Cullen; Terrence J. Priestman; George R. P. Bl πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 352 KB

Idarubicin (4-demethoxydaunorubicin: DMDNR) is an orally active analogue of daunorubicin that has shown promising activity in animal and early clinical studies. We gave idarubicin in a phase II study to patients with advanced breast cancer unresponsive to hormonal manipulation and in some cases to s