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A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin

✍ Scribed by JeanL. Grem; MaryG. Quinn; Bruce Keith; BrianP. Monahan; J.Michael Hamilton; Yan Xu; Nancy Harold; Dat Nguyen; ChrisH. Takimoto; Anthony Rowedder; Janet Pang; Geraldine Morrison; Alice Chen

Publisher
Springer
Year
2003
Tongue
English
Weight
275 KB
Volume
52
Category
Article
ISSN
0344-5704

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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer