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Phase I clinical evaluation of oral and intravenous 4-demethoxydaunorubicin

โœ Scribed by Kavanagh, John J; Yeung, Katherine Y; Savaraj, Niramol; Krakoff, Irwin H

Book ID
122890014
Publisher
Elsevier Science
Year
1985
Weight
301 KB
Volume
21
Category
Article
ISSN
0277-5379

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Phase I trial of 4-demethoxydaunorubicin
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Twenty-four patients with a variety of solid tumors entered a Phase I trial with 4-demethoxydaunorubicin, a new analogue of daunorubicin. The drug was given as a single oral dose of 10-60 mg/m 2 repeated every 3-4 weeks. Leukopenia was the dose-limiting toxicity. Other toxic effects included mild t

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Phase II clinical and pharmacological study of oral 4-demethoxydaunorubicin in advanced non-pretreated small cell lung cancer
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4-Demethoxydaunorubicin (4-DMDNR) is an oral anthracycline with antitumour activity demonstrated in a number of clinical studies. We have assessed the usefulness of 4-DMDNR in 16 patients with advanced small cell lung cancer, none of whom had received previous chemotherapy. There were no complete or