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Clinical phase I trial of marcellomycin with a single-dose schedule

โœ Scribed by Rozencweig, Marcel; De Marneffe, Michel; Crespeigne, Nadine; Dodion, Pierre; Piccart, Martine; Sculier, Jean-Paul; Lenaz, Luigi; Kenis, Yvon; Nicaise, Claude

Book ID
123503216
Publisher
Elsevier Science
Year
1983
Weight
616 KB
Volume
19
Category
Article
ISSN
0277-5379

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Twenty-four patients with a variety of solid tumors entered a Phase I trial with 4-demethoxydaunorubicin, a new analogue of daunorubicin. The drug was given as a single oral dose of 10-60 mg/m 2 repeated every 3-4 weeks. Leukopenia was the dose-limiting toxicity. Other toxic effects included mild t