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Phase I clinical trial of a 3-day divided dose schedule of ifosfamide (NSC 109724)

✍ Scribed by R.L. Nelson; P.J. Creaven; M.H. Cohen; B.E. Fossieck Jr.

Book ID
113145800
Publisher
Elsevier Science
Year
1976
Weight
418 KB
Volume
12
Category
Article
ISSN
0014-2964

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✍ Sen H. Zhuang; Manish Agrawal; Maureen Edgerly; Susan Bakke; Herb Kotz; Paul Tha πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 86 KB

## Abstract ## BACKGROUND The epothilones are a novel class of microtubule‐stabilizing agents. Ixabepilone (BMS‐247550; NSC 710428) is a semisynthetic analog of the natural product epothilone B. The authors conducted a Phase I study by administering ixabepilone to patients as a 1‐hour intravenous