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Phase I clinical trial of lenalidomide in combination with sorafenib in patients with advanced cancer

✍ Scribed by Prasanth Ganesan, Sarina Piha-Paul, Aung Naing, Gerald Falchook, Jennifer Wheler, Siqing Fu, David S. Hong, Razelle Kurzrock, Filip Janku, Shell Laday, Agop Y. Bedikian, Merrill Kies, Robert A. Wolff, Apostolia M. Tsimberidou…show all 14hide


Book ID
120961630
Publisher
Springer US
Year
2013
Tongue
English
Weight
258 KB
Volume
32
Category
Article
ISSN
0167-6997

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi