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Phase I clinical trial of lenalidomide in combination with temsirolimus in patients with advanced cancer

✍ Scribed by Ganesan, Prasanth; Piha-Paul, Sarina; Naing, Aung; Falchook, Gerald; Wheler, Jennifer; Janku, Filip; Zinner, Ralph; Laday, Shell; Kies, Merrill; Tsimberidou, Apostolia M.


Book ID
121089907
Publisher
Springer US
Year
2013
Tongue
English
Weight
341 KB
Volume
31
Category
Article
ISSN
0167-6997

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi