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Phase I Trial of Everolimus Plus Sorafenib for Patients with Advanced Renal Cell Cancer

โœ Scribed by Robert J. Amato; Amber L. Flaherty; Mika Stepankiw

Book ID
113539000
Publisher
CIG Media Group, LP.
Year
2012
Tongue
English
Weight
247 KB
Volume
10
Category
Article
ISSN
1558-7673

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## Abstract ## BACKGROUND. Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dos