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Pharmacological Investigation of 3-(β-dimethylaminoethyl)-2-thio-2,4-[1H, 3H]-quinazoline-dione, hydrochloride (QB 15B)

✍ Scribed by Weis, Jan


Book ID
114798537
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
73 KB
Volume
25
Category
Article
ISSN
0001-6683

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Abstmctz Dialkylation of the title compound occurs regioselectively at C-l. Addition of N,N'-diiethyl-NJ'-propylene urea (DMFV) permits the one-pot synthesis of I,l-dialkylation products in good yields. The asymmetric induction of the stereogenic C-4 center directs the first and the second alkylatio