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Regio- and diastereoselective dialkylation of (4S)-2,4-dimethyl-2,4-dihydro-1H-pirazino[2,1-b]quinazoline-3,6-dione

✍ Scribed by Sonsoles Martín-Santamaría; Modesta Espada; Carmen Avendaño

Book ID
104208193
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
400 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

Abstmctz Dialkylation of the title compound occurs regioselectively at C-l. Addition of N,N'-diiethyl-NJ'-propylene urea (DMFV) permits the one-pot synthesis of I,l-dialkylation products in good yields. The asymmetric induction of the stereogenic C-4 center directs the first and the second alkylation steps.

📜 SIMILAR VOLUMES

ChemInform Abstract: Reactivity as Glyci
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✍ Felix L. Buenadicha; Carmen Avendano; Monica Soellhuber 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Vilsmeier and Mannich reactions on (4S)-
Vilsmeier and Mannich reactions on (4S)-N2-substituted 4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones
✍ María Fernandez; María L. Heredia; Elena de la Cuesta; Carmen Avendaño 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 351 KB

The enamine character of the CH2-C(lla)=N(ll) fragment in the title compounds was studied. Congxatmds I gave l-dimethylaminomethylene products $ after Vilsmeier reaction. The l-formyl derivatives, obtained by alkaline hydrolysis of 5, were isolated as enol tautome~s and were vea'y unstable in acid m