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Regio- and Diastereoselective Alkylation of 2-Substituted 2,4-Dihydro-1 H - pyrazino[2,1- b ]quinazoline-3,6-diones

✍ Scribed by Martín-Santamaría, Sonsoles; Buenadicha, Félix L.; Espada, Modesta; Söllhuber, Mónica; Avendaño, Carmen


Book ID
127229771
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
170 KB
Volume
62
Category
Article
ISSN
0022-3263

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Regio- and diastereoselective dialkylati
✍ Sonsoles Martín-Santamaría; Modesta Espada; Carmen Avendaño 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 400 KB

Abstmctz Dialkylation of the title compound occurs regioselectively at C-l. Addition of N,N'-diiethyl-NJ'-propylene urea (DMFV) permits the one-pot synthesis of I,l-dialkylation products in good yields. The asymmetric induction of the stereogenic C-4 center directs the first and the second alkylatio