Abstmctz Dialkylation of the title compound occurs regioselectively at C-l. Addition of N,N'-diiethyl-NJ'-propylene urea (DMFV) permits the one-pot synthesis of I,l-dialkylation products in good yields. The asymmetric induction of the stereogenic C-4 center directs the first and the second alkylatio
โฆ LIBER โฆ
Structure of (4S)-2,4-dimethyl-1,2-dihydropyrazino[2,1-b]quinazoline-3(4H),6-dione
โ Scribed by Suguna, K. ;Ramakumar, S. ;Rajappa, S.
- Book ID
- 114528546
- Publisher
- International Union of Crystallography
- Year
- 1982
- Weight
- 268 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0567-7408
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The enamine character of the CH2-C(lla)=N(ll) fragment in the title compounds was studied. Congxatmds I gave l-dimethylaminomethylene products $ after Vilsmeier reaction. The l-formyl derivatives, obtained by alkaline hydrolysis of 5, were isolated as enol tautome~s and were vea'y unstable in acid m